The effect of age on prepro-orexin gene expression and contents of orexin A and B in the rat brain

The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

Luı́s de Lecea, Thomas S. Kilduff, Christelle Peyron et al. · Proceedings of the National Academy of Sciences · 1998 · 3.9K citations

Life Sciences, Neurobiology, Neuroscience +15

Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems

Christelle Peyron, Devin K. Tighe, Anthony N. van den Pol et al. · Journal of Neuroscience · 1998 · 3.5K citations · Full text

Medicine, Neurobiology, Neuroscience +14

Narcolepsy in orexin Knockout Mice

Richard M. Chemelli, Jon T. Willie, Christopher M. Sinton et al. · Cell · 1999 · 3.1K citations · Full text

Life Sciences, Neurobiology, Neuroscience +12

The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene

Ling Lin, Juliette Faraco, Robin Li et al. · Cell · 1999 · 2.6K citations · Full text

Medicine, Neurology, Neuroscience +13

Orexin A activates locus coeruleus cell firing and increases arousal in the rat

Jim J. Hagan, Ron A. Leslie, Sara Patel et al. · Proceedings of the National Academy of Sciences · 1999 · 1.2K citations

Life Sciences, Neurobiology, Neuroscience +17