Dag Stenberg

Sleep and its homeostatic regulation in mice lacking the adenosine A₁receptor

Dag Stenberg, Erik Litonius, Linda Halldner et al. · Journal of Sleep Research · 2003 · 147 citations

Noradrenergic activity in rat brain during rapid eye movement sleep deprivation and rebound sleep

Tarja Porkka‐Heiskanen, Sabrina Smith, Tomi Taira et al. · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 1995 · 112 citations

Social Sciences, Rat Brain, Sleep Medicine +22

Adenosine and behavioral state control: adenosine increases c-Fos protein and AP1 binding in basal forebrain of rats

Radhika Basheer, Tarja Porkka‐Heiskanen, Dag Stenberg et al. · Molecular Brain Research · 1999 · 107 citations

Molecular Neuroscience, Molecular Physiology, Behavioral Neuroscience +13

Saliva and serum samples were collected from eight healthy volunteers every two hours during a 26‐hour period. Melatonin concentrations were measured by radioimmunoassay after chloroform extraction using radioiodinated melatonin as a tracer. Five of the subjects had high serum melatonin levels at night (peak levels higher than 75 pg/ml); in three subjects the highest serum melatonin concentration was 20‐40 pg/ml. All subjects had low levels (&lt;10 pg/ml) during the day. The correlations between salivary and serum levels were calculated. The regression line y =0.33×+ 3.7 pg/ml, r= 0.95, <i>P</i> &lt;0.001, was obtained for all detectable value pairs (n= 73). The regression and correlation coefficients were almost equal for the peak values of melatonin and during the rising and descending phases of the secretion patterns. However, no significant correlation was found between low daytime salivary and serum concentrations when calculated separately. In the five high‐secretors the melatonin levels in saliva reflected reliably the changes in serum, but in the three low‐secretors the correlation between salivary and serum melatonin was not significant. The proportion of melatonin found in saliva decreased with increasing serum melatonin levels. Circadian rhythm parameters were estimated by single cosinor analysis. The acrophases did not differ significantly within a subject in the concomitant measurements of serum and salivary melatonin. The measurements of salivary melatonin levels seem valid for studies on melatonin rhythms, but the melatonin concentrations measured in saliva do not always consistently reflect the absolute concentrations in blood.

Maija‐Liisa Laakso, Tarja Porkka‐Heiskanen, Aino Alila et al. · Journal of Pineal Research · 1990 · 106 citations

Visual and spectral EEG analysis in the evaluation of the outcome in patients with ischemic brain infarction

Kimmo Sainio, Dag Stenberg, Ilmo Keskimäki et al. · Electroencephalography and Clinical Neurophysiology · 1983 · 97 citations

Spectral Eeg Analysis, Ischemic Stroke, Medicine +12