Selective Extraction of Peptides from Human Plasma by Highly Ordered Mesoporous Silica Particles for Peptidome Analysis

Abstract

Pores for effect: Silica particles with a pore size of 20.5 Å (see TEM image) are effective for enriching peptides in human plasma over a wide range of molecular weights from 1 to 12 kDa, while repelling most other plasma proteins outside. The pore structure of the material makes it superior for peptide enrichment compared to adsorbent- and ultrafiltration-based methods.