Concepedia

HUMAN IN VITRO GLUTATHIONYL AND PROTEIN ADDUCTS OF CARBAMAZEPINE-10,11-EPOXIDE, A STABLE AND PHARMACOLOGICALLY ACTIVE METABOLITE OF CARBAMAZEPINE

Hai‐Zhi Bu, Ping Kang, Alan Deese, Ping Zhao, William F. Pool

Drug Metabolism and Disposition · 2005 · 79 citations · 13 references

Concepts

MedicinePharmacologyToxicologyClinical PharmacologyMolecular PharmacologyNeuropharmacologyIn Vitro PharmacologyReactive MetabolitesCarbamazepine PharmacologyCovalent Drug BindingCovalent Protein AdductsCovalent Protein BindingEpoxide MetabolitesIdiosyncratic Adverse Drug ReactionsIdiosyncratic Drug ReactionsOxidative Protein Adducts

References

13

Anticonvulsant hypersensitivity syndrome. In vitro assessment of risk.

Neil H. Shear, S P Spielberg · Journal of Clinical Investigation · 1988 · 689 citations · Full text

Medicine, Pharmacology, Toxicology +10

Improved WATERGATE Pulse Sequences for Solvent Suppression in NMR Spectroscopy

Maili Liu, Xi‐an Mao, Chaohui Ye et al. · Journal of Magnetic Resonance · 1998 · 540 citations

Natural Sciences, Chemistry, Physics +6

Anticonvulsant Hypersensitivity Syndrome

Carmela C. Vittorio · Archives of Internal Medicine · 1995 · 423 citations

Medicine, Pharmacology, Pharmacotherapy +15

Carbamazepine and hematological monitoring

Robert G. Hart, J. Donald Easton · Annals of Neurology · 1982 · 138 citations

Medicine, Hematology, Pharmacology +15

Bioactivation of carbamazepine in the rat in vivo. Evidence for the formation of reactive arene oxide(s).

Stephen F. Madden, J.L. Maggs, B K Park · Drug Metabolism and Disposition · 1996 · 98 citations

Pharmacy, Pharmacology, Toxicology +15