Preparation Techniques and Mechanisms of Formation of Biodegradable Nanoparticles from Preformed Polymers

TLDR

Biodegradable nanoparticles from preformed polymers are prepared by several techniques, yet few studies thoroughly analyze the preparative procedures. The review examines four methods—emulsion‑evaporation, solvent displacement, salting‑out, and emulsion‑diffusion—detailing their physicochemical mechanisms of particle formation. It discusses how preparative variables influence particle size and drug‑entrapment efficiency.

Abstract

AbstractThe techniques available to prepare biodegradable nanoparticles (nanospheres and nanocapsules) from preformed polymers are reviewed. Although there is abundant literature on this topic, only a few focus on the thorough analysis of preparative procedures. In particular, four techniques are discussed in terms of their technological advantages and drawbacks: emulsijication evaporation, solvent displacement, salting-out, and emulsijication difision. The proposed mechanism of nanoparticle formation for each technique is described from a physicochemical perspective. The eflects of preparative variables on nanoparticle size and drug-entrapment efficiency are also discussed.Key Words:: NanoparticlesNanospheresNanocapsulesPreparation methodsMechanism of formation