Application of blind source separation to 1-D and 2-D nuclear magnetic resonance spectroscopy

Abstract

We present the application of blind source separation to the processing of mixtures of one-dimensional (1-D) and two-dimensional (2-D) nuclear magnetic resonance subspectra. A spectroscopic technique called distortionless enhancement by polarization transfer (DEPT) allows the generation of three spectra in which the response intensities of the CH, CH/sub 2/, and CH/sub 3/ fragments of organic molecules are modulated according to an experimental parameter. The blind source separation technique offers an attractive way of separating these responses automatically. A scheme that allows the processing of 2-D DEFT-like data sets is presented.