Lithium Chloride Alleviates Neurodegeneration Partly by Inhibiting Activity of GSK3β in a SCA3 Drosophila Model

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Brinda Ravikumar, Zdenek Berger, J. Eric Davies et al. · Nature Genetics · 2004 · 2.3K citations

Life Sciences, Genetics, Neuroscience +17

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

Brinda Ravikumar · Human Molecular Genetics · 2002 · 1.1K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Lithium induces autophagy by inhibiting inositol monophosphatase

Sovan Sarkar, R. Andrés Floto, Zdenek Berger et al. · The Journal of Cell Biology · 2005 · 974 citations · Full text

Life Sciences, Cell Biology, Pharmacology +16

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

Andrea Williams, Sovan Sarkar, Paul A. Cuddon et al. · Nature Chemical Biology · 2008 · 786 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +14

Expanded Polyglutamine Protein Forms Nuclear Inclusions and Causes Neural Degeneration in Drosophila

John M. Warrick, Henry L. Paulson, Quang T Bui et al. · Cell · 1998 · 671 citations · Full text

Life Sciences, Genetics, Neuroscience +17