Expression of GDNF transgene in astrocytes improves cognitive deficits in aged rats

Spatial localization does not require the presence of local cues

Richard Morris · Learning and Motivation · 1981 · 2.7K citations

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Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector.

Luigi Naldini, Ulrike Blömer, Fred H. Gage et al. · Proceedings of the National Academy of Sciences · 1996 · 1.5K citations · Full text

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Direct brain infusion of glial cell line–derived neurotrophic factor in Parkinson disease

Steven S. Gill, Nikunj K. Patel, Gary Hotton et al. · Nature Medicine · 2003 · 1.3K citations

Life Sciences, Neurobiology, Neuroscience +17

GDNF: a Potent Survival Factor for Motoneurons Present in Peripheral Nerve and Muscle

Christopher E. Henderson, Heidi Phillips, Richard A. Pollock et al. · Science · 1994 · 1.3K citations

Life Sciences, Neurobiology, Neuroscience +13

Neurodegeneration Prevented by Lentiviral Vector Delivery of GDNF in Primate Models of Parkinson's Disease

Jeffrey H. Kordower, Marina E. Emborg, Jocelyne Bloch et al. · Science · 2000 · 1.3K citations · Full text

Life Sciences, Neurology, Neuroscience +17