Molecular and Cellular Biology · 2005 · 302 citations · 33 references
Life SciencesGeneticsMolecular BiologyCell CycleCircadian RhythmsDna ReplicationCell Cycle ControlCell Cycle SignalingCell-cycle CheckpointsCell-cycle RegulationCircadian Clock MechanismsCircadian PhysiologyCheckpointsCryptochrome ProteinsDna Damage Checkpoint ActivationDna Damage Checkpoint KinasesDna Damage Checkpoint SignalingDna Damage ResponsesMolecular Clock MechanismsMolecular Clockwork
The Timeless protein is essential for circadian rhythm in Drosophila. The Timeless orthologue in mice is essential for viability and appears to be required for the maintenance of a robust circadian rhythm as well. We have found that the human Timeless protein interacts with both the circadian clock protein cryptochrome 2 and with the cell cycle checkpoint proteins Chk1 and the ATR-ATRIP complex and plays an important role in the DNA damage checkpoint response. Down-regulation of Timeless in human cells seriously compromises replication and intra-S checkpoints, indicating an intimate connection between the circadian cycle and the DNA damage checkpoints that is in part mediated by the Timeless protein.
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Loning Fu, Hélène Pelicano, Jinsong Liu et al. · Cell · 2002 · 1.3K citations · Full text
Posttranslational Mechanisms Regulate the Mammalian Circadian Clock
Choogon Lee, Jean‐Pierre Etchegaray, Felino R. Cagampang et al. · Cell · 2001 · 1.2K citations · Full text
Life Sciences, Biochemistry, Biology +14
Control Mechanism of the Circadian Clock for Timing of Cell Division in Vivo
Takuya Matsuo, Shun Yamaguchi, Shigeru Mitsui et al. · Science · 2003 · 1.1K citations