Clinical Infectious Diseases · 2004 · 195 citations · 11 references
MedicineInternal MedicinePharmacotherapyPulmonologyRespiratory PharmacotherapyVentilationAcute Respiratory Distress SyndromeAcute Respiratory FailureAirway SupportInhalation TherapyRespiratory DiseaseRespiratory MedicineAirway Pressure ManagementChest Radiography FindingsInhaled AdministrationInhaled Nitric Oxide TherapyInhaled TherapiesNitric OxidePulmonary Vasodilator TherapySevere Acute Respiratory Syndrome
Inhalation of nitric oxide (NO) improved arterial oxygenation and enabled the reduction of inspired oxygen therapy and airway pressure support in patients with severe acute respiratory syndrome (SARS). In addition, chest radiography showed decreased spread or density of lung infiltrates, and the physiological effects remained after termination of inhaled NO therapy. These findings suggest not only a pulmonary vasodilator effect of inhaled NO, but also an effect on SARS.
11
Inhaled Nitric Oxide for the Adult Respiratory Distress Syndrome
Rolf Rossaint, K. J. Falke, Frank A. López et al. · New England Journal of Medicine · 1993 · 1.8K citations · Full text
Identification of Severe Acute Respiratory Syndrome in Canada
Susan M. Poutanen, Donald E. Low, Bonnie Henry et al. · New England Journal of Medicine · 2003 · 1.1K citations · Full text