Visualization and Characterization of Inflammatory Cell Recruitment and Migration through the Corneal Stroma in Endotoxin-Induced Keratitis

Abstract

EGFP chimeric mice and ex vivo 3D analysis of whole-mount corneas provides unique information on the interaction of infiltrating inflammatory cells in the cornea. These findings demonstrate that a chemotactic gradient triggered in part by MIP-2 is responsible for directing inflammatory cell migration through the corneal stroma.