Pharmaceutical Development and Technology · 2007 · 16 citations · 13 references
PharmacyPharmaceuticsPharmacologyDrug DeliveryPolymer ChemistryTransdermal Drug DeliveryChemical Penetration EnhancersDrug PermeationPermeability AssessmentPermeability EnhancementPermeation EnhancersSurface ModificationChemical Permeation EnhancersCrystallizationFeasibility Study DesignFeasibility Study PreparationPolyethylenePolymeric Matrix PatchesPolymeric Patch MaterialsStabilized Formulations
The present feasibility study was designed to obtain a monolayer patch containing oxybutynin (OXY) avoiding chemical permeation enhancers. The highest flux was obtained with a polydimethylsiloxane matrix patch. Because OXY crystals were detected in the matrix within a week, two amino methylmethacrylate copolymers (Eudragit E or Eudragit RS) were used as OXY crystallization inhibitors. A preliminary in vivo study indicated that flux from the stabilized patches had to be increased about 30-40%. This goal was reached by occlusion with a polyethylene layer.
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R. Howard Zobrist, Alexander Feick, Danyi Quan et al. · Pharmaceutical Research · 2001 · 79 citations