Novel mutations at RET ligand genes preventing receptor activation are associated to Hirschsprung’s disease

The metabolic and molecular bases of inherited disease

Ying-Tsong Chen · Medical Entomology and Zoology · 2001 · 6.9K citations

Disease Mechanism, Genetic Disorder, Genetics +6

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

Anita Schuchardt, Vivette D. D’Agati, Lena Larsson-Blomberg et al. · Nature · 1994 · 1.6K citations

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Renal and neuronal abnormalities in mice lacking GDNF

Mark W. Moore, Robert D. Klein, Isabel Fariñas et al. · Nature · 1996 · 1.3K citations

Urology, Renal Function, Medicine +6

GFRα1 Is an Essential Receptor Component for GDNF in the Developing Nervous System and Kidney

G Cacalano, Isabel Fariñas, Li-Chong Wang et al. · Neuron · 1998 · 559 citations · Full text

Signal Transduction, Molecular Physiology, Developmental Biology +12

Persephin, a Novel Neurotrophic Factor Related to GDNF and Neurturin

Jeffrey Milbrandt, Frédéric J. de Sauvage, Timothy J. Fahrner et al. · Neuron · 1998 · 497 citations · Full text

Neurology, Neuroscience, Molecular Neurobiology +5