ChemMedChem · 2007 · 17 citations · 11 references
MedicineInfectious DiseasesPharmacologyAntimicrobial PharmacologyChemotherapyDrug DiscoveryAntiparasitic AgentsAntiparasitic Drug ResistanceAntiparasitic PharmacologyAntiparasitic ResistanceEnzyme InhibitionMalariaAntimalarial AgentsAntimalarial ChemotherapyAntimalarial Drug CombinationsAntimalarial Drug DevelopmentDrug Efficacy ReductionParasite Drug ResistancePlasmodium FalciparumTreatment Of Malaria
Combining chemicals. Malaria is one of the most widespread parasitic infections in the world, however, the unavailability of a vaccine and the spread and intensification of drug resistance over the past 15–20 years have led to a dramatic decline in the efficacy of the most affordable antimalarial drugs. Herein, the development of “double-drugs” to tackle inhibition of P. falciparum growth is discussed.
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The global distribution of clinical episodes of Plasmodium falciparum malaria
Robert W. Snow, Carlos A. Guerra, Abdisalan M. Noor et al. · Nature · 2005 · 2.7K citations · Full text
Veterinary Medicine, Health Sciences, Infectious Diseases +14
Jun Liu, Eva S. Istvan, Ilya Y. Gluzman et al. · Proceedings of the National Academy of Sciences · 2006 · 353 citations · Full text