Angewandte Chemie International Edition · 2010 · 349 citations · 49 references
PharmacyPharmaceuticsPharmacologyDrug DeliveryNanomaterialsNanoparticle Drug DeliveryCancer NanomedicineControlled Release MechanismsInorganic NanoparticlesNanocarriers For TherapeuticsNanomaterials For Drug DeliveryNanomedicineControlled ReleaseMesoporous Silica NanomaterialsMesoporous Silica NanoparticlesNanoparticle PharmacologyNanoparticle-based ChemotherapyPh-sensitive NanoparticlesSilica-based NanoparticlesSmart Nanoparticles
Cut here to cure: Doxorubicin attached to pH-sensitive mesoporous silica nanoparticles (MSN-hydrazone-Dox) shows potential in the chemotherapeutic treatment of liver cancer. Hydrolysis of the pH-sensitive hydrazone bond in the acidic environment of endosomes/lysosomes (see picture) releases Dox intracellularly from the MSN nanochannels, resulting in highly efficient apoptotic cell death.
49
A New Property of MCM-41: Drug Delivery System
María Vallet‐Regí, A. Rámila, R. P. del Real et al. · Chemistry of Materials · 2000 · 2.2K citations
Tamotsu Yoshimori, Akira Yamamoto, Yoshinori Moriyama et al. · Journal of Biological Chemistry · 1991 · 1.4K citations · Full text
Size Effect on Cell Uptake in Well‐Suspended, Uniform Mesoporous Silica Nanoparticles
Fang Lu, Si‐Han Wu, Yann Hung et al. · Small · 2009 · 1K citations