Angewandte Chemie International Edition · 2010 · 275 citations · 36 references
Natural SciencesChemistryMedicinal ChemistryDrug DiscoveryOrganic ChemistrySynthetic Medicinal ChemistryChemistry ReviewOrganic SynthesisRetrosynthetic AnalysisAlkylation CatalysisAlkylation ProcessesAlkylation ReactionsGrignard Reagent SynthesisLactam SynthesisMedicinal Chemistry ApplicationsOrganolithium CompoundsOrganolithium Reagent Synthesis
Be dazzled by the sequence: The first efficient and general one-pot method for the reductive bisalkylation of lactams/amides with Grignard and organolithium reagents has been developed (see scheme; DTBMP=2,6-di-tert-butyl-4-methylpyridine, Tf=trifluoromethanesulfonyl).
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