5-Fluorouracil Adjuvant Chemotherapy Does Not Increase Survival in Patients With CpG Island Methylator Phenotype Colorectal Cancer

A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer.

C. Richard Boland, Stephen N. Thibodeau, Stanley R. Hamilton et al. · PubMed · 1998 · 4.1K citations

Life Sciences, Genetics, Oncology +17

Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer

Christine Ribic, Daniel J. Sargent, Malcolm J. Moore et al. · New England Journal of Medicine · 2003 · 2.1K citations · Full text

Medicine, Cancer Biology, Oncology +15

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

Daniel J. Weisenberger, Kimberly D. Siegmund, Mihaela Campan et al. · Nature Genetics · 2006 · 2K citations

Medicine, Genetics, Oncology +17

Defective Mismatch Repair As a Predictive Marker for Lack of Efficacy of Fluorouracil-Based Adjuvant Therapy in Colon Cancer

Daniel J. Sargent, Silvia Marsoni, Geneviève Monges et al. · Journal of Clinical Oncology · 2010 · 1.6K citations · Full text

Medicine, Molecular Biology, Oncology +17

Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines.

M F Kane, Massimo Loda, Gretchen M. Gaida et al. · PubMed · 1997 · 1.5K citations

Life Sciences, Genetics, Oncology +17