Concepedia

NDM-8 Metallo-β-Lactamase in a Multidrug-Resistant Escherichia coli Strain Isolated in Nepal

Tatsuya Tada, Tohru Miyoshi‐Akiyama, Rajan K. Dahal, Manoj Kumar Sah, Hiroshi Ohara, Teruo Kirikae, Bharat Mani Pokhrel

Antimicrobial Agents and Chemotherapy · 2013 · 59 citations · 20 references

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Abstract

A novel metallo-β-lactamase, NDM-8, was identified in a multidrug-resistant Escherichia coli isolate, IOMTU11 (NCGM37), obtained from the respiratory tract of a patient in Nepal. The amino acid sequence of NDM-8 has substitutions at positions 130 (Asp to Gly) and 154 (Met to Leu) compared with NDM-1. NDM-8 showed enzymatic activities against β-lactams similar to those of NDM-1.

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