Low Levels of Protein C Are Associated With Poor Outcome in Severe Sepsis

The Effects of Ibuprofen on the Physiology and Survival of Patients with Sepsis

Gordon R. Bernard, Arthur P. Wheeler, James A. Russell et al. · New England Journal of Medicine · 1997 · 833 citations

Medicine, Pharmacology, Pharmacotherapy +17

Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon.

Fletcher B. Taylor, Alvin Chang, CT Esmon et al. · Journal of Clinical Investigation · 1987 · 829 citations · Full text

Veterinary Medicine, Biochemistry, Pharmacology +17

Septic Shock, Multiple Organ Failure, and Disseminated Intravascular Coagulation

François Fourrier, C Chopin, Jenny Goudemand et al. · CHEST Journal · 1992 · 707 citations

Veterinary Medicine, Infectious Diseases, Pathobiology +16

The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex.

Deborah J. Stearns-Kurosawa, Shinichiro Kurosawa, Jeffery S. Mollica et al. · Proceedings of the National Academy of Sciences · 1996 · 528 citations

Life Sciences, Biochemistry, Molecular Biology +17

Toward an Epidemiology and Natural History of SIRS (Systemic Inflammatory Response Syndrome)

Roger C. Bone · JAMA · 1992 · 490 citations

Veterinary Medicine, Immunology, Immunopathology +8