Use of baseline measurements in the two-period crossover design

Abstract

It is proposed that baseline measurements be obtained prior to each period in a two-period crossover design. These measurements are used in a preliminary test for determining the validity of a test for treatment comparison and also for testing the hypothesis of equal treatment effects. The null hypothesis in this preliminary test consists of the following three hypotheses: that there is no difference in disease conditions prior to the two periods, no difference in residual effects of the drugs, and no treatment × period interaction.. A numerical example is given and the efficiencies of several methods are computed.