Concepedia

Randomized Two-period Design

A Randomized Two-Period Design is a crossover experimental design, belonging to the class of bioequivalence study designs, in which each participant is randomly assigned to receive either the test and reference formulations in one sequence or the reverse sequence across two treatment periods, thereby enabling intra-subject comparison while controlling for order effects through randomization.

360

Publications

19.9K

Citations

1.4K

Authors

452

Institutions

Publications per year

2017–2026

95

Variants

2X2 Crossover DesignTwo-period Crossover Design

Parents

Publications

360

Meta-analyses involving cross-over trials: methodological issues

Diana R Elbourne, Douglas G. Altman, Julian P. T. Higgins et al. · International Journal of Epidemiology · 2002 · 2.3K citations · Full text

, , +11

Experimental designs, 2nd ed.

William G. Cochran, Gertrude M. Cox · 1957 · 1.7K citations

, , +10

Breaking Up Prolonged Sitting Reduces Postprandial Glucose and Insulin Responses

David W. Dunstan, Bronwyn A. Kingwell, Robyn N. Larsen et al. · Diabetes Care · 2012 · 1.2K citations · Full text

, , +14

The Two-Period Change-Over Design and Its Use in Clinical Trials

James E. Grizzle · Biometrics · 1965 · 788 citations

, , +13

328. Note: The Use of None-Parametric Methods in the Statistical Analysis of the Two-Period Change-Over Design

Gary G. Koch · Biometrics · 1972 · 468 citations

, , +6

1–5 of 360

Authors

1.4K

  1. HI
    H. I. Patel

    Novartis (Switzerland), Switzerland

    4 publications · 113 citations

    4

    h-index

  2. WH
    William H. Sauer

    University of Colorado Denver, United States

    4 publications · 272 citations

    4

    h-index

  3. KC
    Keumhee C. Carrière

    University of Alberta, Canada

    3 publications · 94 citations

    3

    h-index

  4. LT
    L. T. Egbeyale

    Federal University of Agriculture, Nigeria

    3 publications · 102 citations

    3

    h-index

  5. JN
    J. N. S. Matthews

    Newcastle University, United Kingdom

    3 publications · 67 citations

    3

    h-index

1–5 of 1.4K

Institutions

452

  1. Diponegoro University

    Semarang, Indonesia

    7 h-index

    22 publications

    531 citations

  2. University of Alberta

    Edmonton, Canada

    6 h-index

    13 publications

    447 citations

  3. Universidade Estadual Paulista (Unesp)

    São Paulo, Brazil

    4 h-index

    18 publications

    352 citations

  4. Universitas Gadjah Mada

    Yogyakarta, Indonesia

    4 h-index

    11 publications

    176 citations

  5. Udayana University

    Denpasar, Indonesia

    4 h-index

    8 publications

    125 citations

  6. Padjadjaran University

    Bandung, Indonesia

    4 h-index

    14 publications

    221 citations

  7. University of Manitoba

    Winnipeg, Canada

    4 h-index

    11 publications

    249 citations

  8. Hasanuddin University

    Makassar, Indonesia

    4 h-index

    9 publications

    139 citations

1–8 of 452

Venues

  1. Journal of Animal Science

    18 publications · 1.1K citations

    14

    h-index

  2. Biometrics

    12 publications · 2.1K citations

    12

    h-index

  3. Poultry Science

    11 publications · 496 citations

    11

    h-index

  4. International Journal of Poultry Science

    10 publications · 237 citations

    10

    h-index

  5. Biometrika

    7 publications · 228 citations

    7

    h-index

1–5