DISAGGREGATION OF BRAIN POLYSOMES AFTER ADMINISTRATION OF <i>d</i>‐LYSERGIC ACID DIETHYLAMIDE (LSD) <i>IN VIVO</i>

Abstract

Abstract— Polysomes from three major brain regions of the young rabbit were disaggregated after in vivo administration of d ‐LSD. The effect was transient and demonstrated maximal shift after 30–60 min with a return to normal levels by 4 h. Brain polysome disaggregation was elicited by LSD dosages of either 10 or 100/μg/kg body wt. The polysome shift was not caused by RNase degradation and during maximal disaggregation there was a measurable decrease in protein synthesis.