Catalytic Enantioselective Hosomi–Sakurai Conjugate Allylation of Cyclic Unsaturated Ketoesters

Abstract

No fancy catalyst required: The copper-catalyzed enantioselective conjugate allylation of activated cyclic enones affords products in up to >98 % ee. Reactions proceed to high conversion in the presence of commercially available Cu(OTf)2 and bis(oxazoline) ligand 1. The allylated products are useful precursors for the synthesis of chiral building blocks. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.