Acta Pharmacologica et Toxicologica · 1975 · 39 citations · 20 references
PharmacyNephrologyPharmacokineticsExcretionRenal PharmacokineticsSwine MedicineRenal ClearanceRenal Drug ClearanceRenal Drug DistributionRenal ExcretionRenal PhysiologyTubular SecretionBack DiffusionRenal Drug ExcretionRenal Elimination KineticsRenal Excretion RateRenal Half-lifeUrinary Excretion Half-life
Abstract: Experiments in swine showed that the half‐life of trimethoprim was on an average 2 hours 15 minutes and the apparent volume of distribution was 1.4. In addition to glomerular filtration both active tubular secretion and back diffusion are involved in the renal handling of trimethoprim. The back diffusion is greatly influenced by the pH of the urine.
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Fundamentals of Drug Metabolism and Drug Disposition
M. Lawrence Berman · Anesthesiology · 1973 · 263 citations