TRIMETHOPRIM, A SULPHONAMIDE POTENTIATOR

Abstract

The sulphonamides maintain a considerable place, relatively constant in scope, in the armamentarium of agents useful in bacterial infections (Jukes & Broquist, 1963; Zbinden, 1964).The possibility has existed for some years that their effectiveness might be extended through their conjoint use with inhibitors of bacterial dihydrofolate reductases.This could be shown, in vitro, in diverse microbial growth systems (Hitchings, 1961;