The Journal of Experimental Medicine · 1935 · 434 citations · 0 references
Life SciencesNeurologyNeuroscienceNeurobiology Of DiseaseNeurodegenerationNeuroimmunologyDemyelinating DiseasesDemyelinating DisordersEncephalitisMultiple SclerosisNervous TissueNeuroinflammationCentral Nervous System MyelinationEmulsionsMyelin FormationMyelin PathologyMyelination DisruptionPathological Science
The repeated intramuscular injections of aqueous emulsions and alcohol-ether extracts of sterile normal rabbit brains in some manner produced pathological changes accompanied by myelin destruction in the brains of 7 of 8 monkeys (Macacus rhesus). Eight, control monkeys remained well. Cultures from the involved brains remained sterile, and no transmissible agent was demonstrated by means of intracerebral inoculations of emulsions of bits of the brains into monkeys, rabbits, guinea pigs, and white mice.