The Journal of Experimental Medicine · 1935 · 432 citations · 0 references
Neurological DisorderSocial SciencesNeuroregenerationExperimental NeuropathologyNeurologyNeuropathologyNeuroimmunologyNeuropharmacologyEncephalitisNervous SystemPharmacologyControl MonkeysRepeated Intramuscular InjectionsNeurophysiologyNeuroanatomyMyelin DestructionNeuroscienceMultiple SclerosisCentral Nervous SystemMedicine
The repeated intramuscular injections of aqueous emulsions and alcohol-ether extracts of sterile normal rabbit brains in some manner produced pathological changes accompanied by myelin destruction in the brains of 7 of 8 monkeys (Macacus rhesus). Eight, control monkeys remained well. Cultures from the involved brains remained sterile, and no transmissible agent was demonstrated by means of intracerebral inoculations of emulsions of bits of the brains into monkeys, rabbits, guinea pigs, and white mice.