Concepedia

Genetic Polymorphism in <i>ATG16L1</i> Gene Influences the Response to Adalimumab in Crohn’s Disease Patients

Silvo Koder, Katja Repnik, Ivan Ferkolj, Cvetka Pernat, Pavel Skok, Rinse K. Weersma, Uroš Potočnik

Pharmacogenomics · 2015 · 63 citations · 53 references

DOI

Abstract

Our results suggest ADA response in CD patients is genetically predisposed by SNPs in CD risk genes and suggest ATG16L1 as most promising candidate gene for drug response in ADA treatment. Original submitted 24 September 2014; Revision submitted 1 December 2014.

References

53

The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications

Jack Satsangi · Gut · 2006 · 3.1K citations · Full text

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A Genome-Wide Association Study Identifies <i>IL23R</i> as an Inflammatory Bowel Disease Gene

Richard H. Duerr, Kent D. Taylor, Steven R. Brant et al. · Science · 2006 · 3K citations · Full text

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Adalimumab for Maintenance of Clinical Response and Remission in Patients With Crohn’s Disease: The CHARM Trial

Jean–Frédéric Colombel, William J. Sandborn, Paul Rutgeerts et al. · Gastroenterology · 2006 · 2.2K citations

, , +7

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

Jochen Hampe, André Franke, Philip Rosenstiel et al. · Nature Genetics · 2006 · 1.9K citations

, , +9

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

John D. Rioux, Ramnik J. Xavier, Kent D. Taylor et al. · Nature Genetics · 2007 · 1.7K citations · Full text

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