Pharmacogenomics · 2015 · 63 citations · 53 references
Life SciencesImmunologyMolecular GeneticsImmunogeneticsImmunotherapyMedical GeneticsAutoimmune Disease Susceptibility GenesAutoimmune DiseasesAutoimmune InflammationGastrointestinal InflammationImmune-mediated Inflammatory DiseasesInflammatory Bowel DiseaseAtg16l1 FunctionImmune Response Gene VariantsInflammatory Bowel Disease GeneticsInflammatory Gene VariantsMonitoring Therapy ResponseTherapy Response MonitoringTherapy Response StratificationTreatment Response Biomarkers
AIM: To see if SNPs could help predict response to biological therapy using adalimumab (ADA) in Crohn's disease (CD). MATERIALS & METHODS: IBDQ index and CRP levels were used to monitor therapy response. We genotyped 31 CD-associated genes in 102 Slovenian CD patients. RESULTS: The strongest association for treatment response defined as decrease in CRP levels was found for ATG16L1 SNP rs10210302. Additional SNPs in 7 out of 31 tested CD-associated genes (PTGER4, CASP9, IL27, C11orf30, CCNY, IL13, NR1I2) showed suggestive association with ADA response. CONCLUSION: Our results suggest ADA response in CD patients is genetically predisposed by SNPs in CD risk genes and suggest ATG16L1 as most promising candidate gene for drug response in ADA treatment. Original submitted 24 September 2014; Revision submitted 1 December 2014.
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