Access to Guaianolides: Highly Efficient Stereocontrolled Total Synthesis of (±)‐Geigerin

Abstract

Geiger counter: The first total synthesis of geigerin (3), a member of the guaian-8,12-olides, has been achieved in eight regio- and stereocontrolled steps from the tropylium cation. En route, the guaian-6,12-olide 2 is formed in two steps from the hydroazulenone 1, a versatile intermediate.