Molecular Cancer · 2008 · 55 citations · 22 references
The results from this study suggest that phenylbutyrate may have therapeutic utility as a cisplatin sensitizer in head and neck cancer by inhibiting the FA/BRCA pathway through the down regulation of BRCA1 as well as by an FA/BRCA-independent mechanism.
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Interaction of the Fanconi Anemia Proteins and BRCA1 in a Common Pathway
Irene García-Higuera, Toshiyasu Taniguchi, Shridar Ganesan et al. · Molecular Cell · 2001 · 1.2K citations · Full text
Disruption of the Fanconi anemia–BRCA pathway in cisplatin-sensitive ovarian tumors
Toshiyasu Taniguchi, Marc Tischkowitz, Najim Ameziane et al. · Nature Medicine · 2003 · 540 citations · Full text
BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis.
Jennifer E. Quinn, Richard D. Kennedy, Paul B. Mullan et al. · PubMed · 2003 · 402 citations