Palladium‐Catalyzed Sequential Formation of CC Bonds: Efficient Assembly of 2‐Substituted and 2,3‐Disubstituted Quinolines

Abstract

A series of substituted quinolines was prepared from arylamines, aldehydes, and terminal olefins (see scheme). The palladium-catalyzed sequential formation of C-C bonds proceeds smoothly with both electron-deficient and electron-rich olefins. When acrylic acid is used as terminal olefin, decarboxylation occurs to provide 2-substituted quinolines.