Remote <i>meta</i>‐CH Olefination of Phenylacetic Acids Directed by a Versatile U‐Shaped Template

Abstract

meta-C-H olefination of phenylacetic acid derivatives has been achieved using a commercially available nitrile-containing template. The identification of N-formyl-protected glycine as the ligand (Formyl-Gly-OH) was crucial for the development of this reaction. Versatility of the template approach in accommodating macrocyclopalladation processes with different ring sizes is demonstrated.