Current Pharmacological Management in Juvenile Huntington’s Disease

Abstract

SUMMARY BACKGROUND: The clinical presentation of Juvenile Huntington's Disease (JHD) can be very different from adult-onset HD with little evidence to guide symptomatic management. AIM: To survey the current use of pharmacological treatments for JHD. METHODS: Patients were identified through the HD Association, Hospital Doctors and the European Huntington's Disease Network REGISTRY study. RESULTS: The most commonly prescribed agents were anti-psychotics (24/45), anti-depressants (17/45) and anti-parkinsonian medications (15/45). 5 patients were taking more than 8 medications. CONCLUSIONS: The most commonly prescribed group of medication was the anti-psychotic. Many patients were on multiple therapies, highlighting the need to rationalise medications.