Early Hepatic Insulin Resistance Precedes the Onset of Diabetes in Obese C57BLKS-<i>db/db</i> Mice

Abstract

Our study demonstrates the presence of metabolic derangements in BKS-db before the onset of beta-cell failure and identifies early hepatic insulin resistance as a component of the BKS-db phenotype. We propose that defects in hepatic insulin signaling contribute to the development of diabetes in the BKS-db mouse strain.