Concepedia

Gold-mediated bifunctional modification of oligosaccharidesvia a three-component coupling reaction

Karen Ka‐Yan Kung, Gai-Li Li, Lan Zou, Hiu-Chi Chong, Yun‐Chung Leung, Ka‐Hing Wong, Vanessa Kar‐Yan Lo, Chi‐Ming Che, Man‐Kin Wong

Organic & Biomolecular Chemistry · 2011 · 46 citations · 41 references

DOI

Concepts

Abstract

An efficient modular approach for single-site incorporation of two independent functionalities (amines and alkynes) into aldehyde-containing oligosaccharides concurrently by using a one-pot gold-mediated three-component coupling reaction in aqueous medium under mild conditions has been developed.

References

41

A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes

Vsevolod V. Rostovtsev, Luke G. Green, Valery V. Fokin et al. · Angewandte Chemie International Edition · 2002 · 11.5K citations

, , +8

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

Ellen M. Sletten, Carolyn R. Bertozzi · Angewandte Chemie International Edition · 2009 · 3.1K citations · Full text

, , +5

Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry

Hui Zhang, Xiaojun Li, Daniel Martin et al. · Nature Biotechnology · 2003 · 1.4K citations

, , +17

Hydrolytic Stability of Hydrazones and Oximes

Jeet Kalia, Ronald T. Raines · Angewandte Chemie International Edition · 2008 · 879 citations · Full text

, , +10

A Highly Efficient Three-Component Coupling of Aldehyde, Alkyne, and Amines via C−H Activation Catalyzed by Gold in Water

Chunmei Wei, Chao‐Jun Li · Journal of the American Chemical Society · 2003 · 650 citations

, , +14