Cannabidiolic acid prevents vomiting in <i><scp>S</scp>uncus murinus</i> and nausea‐induced behaviour in rats by enhancing 5‐<scp>HT_1A</scp> receptor activation

Abstract

Compared with cannabidiol, CBDA displays significantly greater potency at inhibiting vomiting in shrews and nausea in rats, and at enhancing 5-HT(1A) receptor activation, an action that accounts for its ability to attenuate conditioned gaping in rats. Consequently, CBDA shows promise as a treatment for nausea and vomiting, including anticipatory nausea for which no specific therapy is currently available.