<i>POLE</i> Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer

Abstract

Ultramutated POLE proofreading-mutant endometrial cancers are characterized by a robust intratumoral T-cell response, which correlates with, and may be caused by an enrichment of antigenic neopeptides. Our study provides a plausible mechanism for the excellent prognosis of these cancers.