Concepedia

Pole Mutations

POLE Mutations is a molecular genetic alteration in the DNA polymerase epsilon gene characterized by ultramutated endometrial tumors with high tumor mutational burden and distinct clinical and prognostic implications.

173

Publications

21.7K

Citations

1.8K

Authors

575

Institutions

Publications per year

2017–2026

128

Variants

Pole Gene Mutations

Parents

Publications

173

Integrated genomic characterization of endometrial carcinoma

Nature · 2013 · 5.8K citations · Full text

, , +17

Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

Claire Palles, Jean‐Baptiste Cazier, Kimberley Howarth et al. · Nature Genetics · 2012 · 1K citations · Full text

, , +14

Improved Risk Assessment by Integrating Molecular and Clinicopathological Factors in Early-stage Endometrial Cancer—Combined Analysis of the PORTEC Cohorts

Ellen Stelloo, Remi A. Nout, Elisabeth M. Osse et al. · Clinical Cancer Research · 2016 · 858 citations

, , +17

Molecular Classification of the PORTEC-3 Trial for High-Risk Endometrial Cancer: Impact on Prognosis and Benefit From Adjuvant Therapy

Alicia León‐Castillo, Stephanie M. de Boer, Melanie Powell et al. · Journal of Clinical Oncology · 2020 · 837 citations · Full text

, , +17

Association of Polymerase e–Mutated and Microsatellite-Instable Endometrial Cancers With Neoantigen Load, Number of Tumor-Infiltrating Lymphocytes, and Expression of PD-1 and PD-L1

Brooke E. Howitt, Sachet A. Shukla, Lynette M. Sholl et al. · JAMA Oncology · 2015 · 685 citations · Full text

, , +17

1–5 of 173

Authors

1.8K

  1. TB
    Tjalling Bosse

    Leiden University Medical Center, Netherlands

    20 publications · 4.1K citations

    18

    h-index

  2. RA
    Robert A. Soslow

    Memorial Sloan Kettering Cancer Center, United States

    13 publications · 2K citations

    13

    h-index

  3. MK
    Martin Köbel

    University of Calgary, Canada

    13 publications · 1.4K citations

    13

    h-index

  4. DN
    David N. Church

    University of Oxford, United Kingdom

    12 publications · 2.1K citations

    12

    h-index

  5. IT
    Ian Tomlinson

    Centre for Human Genetics, United Kingdom

    12 publications · 2.5K citations

    12

    h-index

1–5 of 1.8K

Institutions

575

  1. University of British Columbia

    Vancouver, Canada

    19 h-index

    99 publications

    7.8K citations

  2. Memorial Sloan Kettering Cancer Center

    New York, United States

    18 h-index

    143 publications

    20.8K citations

  3. Leiden University Medical Center

    Leiden, The Netherlands

    16 h-index

    115 publications

    24.4K citations

  4. Centre for Human Genetics

    Oxford, United Kingdom

    14 h-index

    54 publications

    25K citations

  5. University of Oxford

    Oxford, United Kingdom

    13 h-index

    71 publications

    27.3K citations

  6. University of Calgary

    Calgary, Canada

    13 h-index

    25 publications

    2.4K citations

  7. Vancouver General Hospital

    Vancouver, Canada

    12 h-index

    43 publications

    4.5K citations

  8. Harvard University

    Cambridge, United States

    10 h-index

    37 publications

    9.4K citations

1–8 of 575

Venues

  1. The American Journal of Surgical Pathology

    11 publications · 612 citations

    11

    h-index

  2. Gynecologic Oncology

    11 publications · 815 citations

    11

    h-index

  3. Clinical Cancer Research

    8 publications · 1.8K citations

    8

    h-index

  4. The Journal of Pathology

    7 publications · 1.7K citations

    7

    h-index

  5. International Journal of Gynecological Cancer

    5 publications · 194 citations

    5

    h-index

1–5