CONTINUING OBSERVATIONS ON THE REGULATORY EFFECTS OF DONOR-SPECIFIC BONE MARROW CELL INFUSIONS AND CHIMERISM IN KIDNEY TRANSPLANT RECIPIENTS1

Abstract

It is concluded that the establishment of a chimeric state in DBMC-infused recipients, albeit of relatively low magnitude (approximately 1% at 2 years in recipient iliac crest bone marrow), has had a definite regulatory effect on immune responses. These results, therefore, add weight to the "causal" horn of the dilemma as to whether donor cell chimerism is a cause or an effect of