PubMed · 1976 · 45 citations · 12 references
Life SciencesCell BiologyPharmacologyCell CycleCell DivisionCellular PharmacologyCell Cycle ControlCell Cycle PharmacologyCell Cycle SignalingCell Cycle TransitionsCytotoxic ChemotherapyCell Cycle AnalysisCell Proliferation KineticsExposure Time DependenceG2 Phase ControlG2 Phase DurationG2 Phase ProgressionG2 Phase RegulationPhase Sensitivity
The kinetic response of a human lymphoma cell line to bleomycin has been analyzed, using an ICP-11 pulse cytophotometer. Bleomycin induced a delay of the cell-cycle traverse in G2 phase, the extent and recovery of which depended on drug concentration, exposure time, and cell cycle stage where treatment was applied. Different phase sensitivity for lethal damage (G2 phase) and kinetic response (early S phase) were documented. Recovery from G2 block did not predict for unimpaired reproductive capacity.
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Pulse cytophotometric analysis of synchronized cells in vitro.
Barthel Barlogie, Benjamin Drewinko, D. A. Johnston et al. · PubMed · 1976 · 93 citations
Bleomycin as a possible synchronizing agent for human tumor cells in vivo.
S. C. Barranco, James K. Luce, Marvin M. Romsdahl et al. · PubMed · 1973 · 89 citations
Medicine, Cell Biology, Oncology +13