PubMed · 1971 · 220 citations · 0 references
Life SciencesCell BiologyPharmacologyCell CycleCell DivisionCell ProliferationAnimal Cell CultureCell Cycle PharmacologyCytotoxic ChemotherapyMitosisAntiproliferative Drug ActionChinese Hamster Ovary CellsG1 Phase ProgressionG1-s Phase TransitionG2 Phase ControlG2 Phase ProgressionG2 Phase RegulationMitosis-related Cytotoxicity
Summary Bleomycin is most effective at killing Chinese hamster ovary cells in mitosis and in G2 phase. Mitosis is the most sensitive phase. In order of increasing resistance were cells treated in G2 phase, early S phase, late S phase, and G1 phase. Interference with cell progression occurred only in cell populations treated with Bleomycin in G2 phase.