The Plant Cell · 1992 · 121 citations · 17 references
AgricultureGeneticsPlant SciencesPlant BiochemistryPlant GeneticsPlant Molecular BiologyDisease ResistanceDisease Resistance GeneticsMolecular Basis Of ResistancePlant Disease ResistancePlant-pathogen InteractionsPlant-pathogenic FungiBiochemical CharacterizationEnzymatic Toxin ActivityEnzyme ActivityPathogen Resistance GenesPlant Disease Resistance GenesPlant Resistance GenesPlant Resistance ResponsesToxin Resistance
In maize, major resistance to the pathogenic fungus Cochliobolus (Helminthosporium) carbonum race 1 is determined by the dominant allele of the nuclear locus hm. The interaction between C. carbonum race 1 and maize is mediated by a pathogen-produced, low molecular weight compound called HC-toxin. We recently described an enzyme from maize, called HC-toxin reductase, that inactivates HC-toxin by pyridine nucleotide-dependent reduction of an essential carbonyl group. We now report that this enzyme activity is detectable only in extracts of maize that are resistant to C. carbonum race 1 (genotype Hm/Hm or Hm/hm). In several genetic analyses, in vitro HC-toxin reductase activity was without exception associated with resistance to C. carbonum race 1. The results indicate that detoxification of HC-toxin is the biochemical basis of Hm-specific resistance of maize to infection by C. carbonum race 1.
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O. C. Yoder · Annual Review of Phytopathology · 1980 · 334 citations
The structure of the toxin from helminthosporium carbonum
Michael L. Gross, David A. McCrery, Frank W. Crow et al. · Tetrahedron Letters · 1982 · 100 citations