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The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18.

N-terminal PartSignal TransductionSignaling PathwayLigand-dependent Activation FunctionNatural SciencesReceptor Tyrosine KinaseReceptor (Biochemistry)Molecular BiologyGene RegulationOncogenic Protein T18Gene ExpressionMedicineCell BiologyCell Signaling