Journal of Virology · 2001 · 20 citations · 40 references
Life SciencesCell BiologyMolecular BiologyMolecular VirologyNuclear OrganizationVirologyNuclear-cytoplasmic TransportRna ExportViral EntryViral GeneticsViral ReplicationViral Rna BiologyNuclear Export PathwaysProtein Nuclear ExportSmall Nucleolar Rna ExportViral Genome PackagingViral Nuclear EntryViral Protein TraffickingViral Rna ExportViral Rna Packaging
The human immunodeficiency virus type 1 Vpr protein is both packaged into virions and efficiently localized to the nucleus. In this report, we show that a significant fraction of Vpr also accumulates in the cytoplasm of virus-producing cells. Although Vpr shuttles between the nucleus and the cytoplasm, studies with an export-deficient Vpr mutant reveal that nuclear export is not required for virion incorporation.
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CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals
Maarten Fornerod, Mutsuhito Ohno, Minoru Yoshida et al. · Cell · 1997 · 2.1K citations · Full text
CRM1 is responsible for intracellular transport mediated by the nuclear export signal
Makoto Fukuda, Shiro Asano, Takahiro Nakamura et al. · Nature · 1997 · 1.2K citations