Characterization of P-glycoprotein Inhibition by Major Cannabinoids from Marijuana

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

Carlos Cordon‐Cardo, James P. O’Brien, D Casals et al. · Proceedings of the National Academy of Sciences · 1989 · 1.7K citations · Full text

Medicine, Oncology, Pharmacology +16

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

Alfred H. Schinkel, Els Wagenaar, Liesbeth van Deemter et al. · Journal of Clinical Investigation · 1995 · 1.1K citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

MDR1 P-Glycoprotein Is a Lipid Translocase of Broad Specificity, While MDR3 P-Glycoprotein Specifically Translocates Phosphatidylcholine

Ardy van Helvoort, Alexander J. Smith, Hein Sprong et al. · Cell · 1996 · 867 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +11

Prevalence of Marijuana Use Disorders in the United States

Wilson M. Compton, Bridget F. Grant, James D. Colliver et al. · JAMA · 2004 · 537 citations

Nursing, Behavioral Sciences, Psychiatry +16

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

Saibal Dey, Murali Ramachandra, Ira Pastan et al. · Proceedings of the National Academy of Sciences · 1997 · 336 citations

Medicine, Molecular Biology, Pharmacology +14