Concepedia

MDR1 P-Glycoprotein Is a Lipid Translocase of Broad Specificity, While MDR3 P-Glycoprotein Specifically Translocates Phosphatidylcholine

Ardy van Helvoort, Alexander J. Smith, Hein Sprong, Ingo Fritzsche, Alfred H. Schinkel, Piet Borst, Gerrit van Meer

Cell · 1996 · 866 citations · 37 references

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37

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Alfred H. Schinkel, Jasper Smit, Olaf van Tellingen et al. · Cell · 1994

+6

2.3K citations

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

Jasper Smit, Alfred H. Schinkel, Ronald P.J. Oude Elferink et al. · Cell · 1993

+11

1.5K citations

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

Alfred H. Schinkel, Els Wagenaar, Liesbeth van Deemter et al. · Journal of Clinical Investigation · 1995

+16

1.1K citations

Platelet-activating factor.

S M Prescott, Guy A. Zimmerman, Thomas M. McIntyre · Journal of Biological Chemistry · 1990

893 citations

Phosphatidylcholine translocase: A physiological role for the mdr2 gene

Stephan Ruetz · Cell · 1994

+4

602 citations