Resolution of 3-(methylamino)-1-(2-thienyl)propan-1-ol, a new key intermediate for duloxetine, with (S)-mandelic acid

Asymmetric synthesis and absolute stereochemistry of LY248686

Jack B. Deeter, Jeff Frazier, G. S. STATEN et al. · Tetrahedron Letters · 1990 · 82 citations

Natural Sciences, Chemistry, Medicinal Chemistry +10

Chiral discrimination upon crystallisation of the diastereomeric salts of 1-arylethylamines with mandelic acid or p-methoxymandelic acid: interpretation of the resolution efficiencies on the basis of the crystal structures

Kazushi Kinbara, Kenichi Sakai, Yukihiko Hashimoto et al. · Journal of the Chemical Society Perkin Transactions 2 · 1996 · 56 citations

Natural Sciences, Chemistry, Crystal Structure +15

Design of resolving reagents: p-substituted mandelic acids as resolving reagents for 1-arylalkylamines

Kazushi Kinbara, Kenichi Sakai, Yukihiko Hashimoto et al. · Tetrahedron Asymmetry · 1996 · 54 citations

Natural Sciences, Chemistry, Medicinal Chemistry +3

Chemo-enzymatic synthesis of the antidepressant duloxetine and its enantiomer

Huiling Liu, T. Anthonsen · Chirality · 2000 · 51 citations

Pharmacy, Chemistry, Medicinal Chemistry +14

Optical Resolution of 1-(3-Methoxyphenyl)ethylamine with Enantiomerically Pure Mandelic Acid, and the Crystal Structure of Less-Soluble Diastereomeric Salt

Kenichi Sakai, Yukihiko Hashimoto, Kazushi Kinbara et al. · Bulletin of the Chemical Society of Japan · 1993 · 23 citations

Natural Sciences, Chemistry, Medicinal Chemistry +11