<scp>pH</scp> ‐Evoked Dural Afferent Signaling Is Mediated by <scp>ASIC3</scp> and Is Sensitized by Mast Cell Mediators

Abstract

These data indicate that the predominant ASIC subtype responding to decreased meningeal pH is ASIC3. Additionally, they demonstrate that in the presence of inflammation, dural afferents respond to even smaller decreases in pH providing further support for the ability of small pH changes within the meninges to initiate afferent input leading to headache.