Magnetic Resonance in Chemistry · 2002 · 32 citations · 29 references
PharmacyPharmaceutical AnalysisAnalytical ChemistryChromatographic AnalysisDrug DiscoveryChiral ChromatographyChiral SeparationChromatographyCyclodextrin ChemistryLigand BindingLiquid ChromatographyBinding ConstantsCyclodextrin DerivatizationCyclodextrin Inclusion ComplexesDiffusion CoefficientsEnantiomeric SeparationMolecular Inclusion ComplexesNuclear Magnetic Resonance Spectroscopy Of CyclodextrinsSupramolecular Inclusion Complexes
Abstract Complexation‐induced chemical shifts and diffusion coefficients (HR‐DOSY) of enantiomers with native and derivatized cyclodextrins were used for calculations of the apparent binding constants of three cyclohexanone inclusion complexes. Correlations between these data and high‐performance liquid chromatography were established, revealing that this approach can be applied as an alternative method to predict enantiomeric discrimination. Copyright © 2002 John Wiley & Sons, Ltd.
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