Angewandte Chemie International Edition · 2009 · 26 citations · 19 references
Life SciencesBiochemistryMolecular BiologyEnzyme MechanismEnzymologyMetabolismCatalytic MechanismsEnzyme FunctionEnzyme InhibitionEnzyme KineticsEnzyme-substrate RecognitionNicotinamide Adenine Dinucleotide MetabolismGlucose-6-phosphate Dehydrogenase RegulationInhibition MechanismsNad+-dependent EnzymesNad-dependent EnzymesNicotinamide Adenine Dinucleotide (Nad+) MetabolismNicotinamide Adenine Dinucleotide ReductasesNicotinamide Riboside Metabolism
Triple duty: A synthetic molecular clip traps nicotinamide adenine dinucleotide phosphate (NADP(+); see picture) as well as occupying both the cofactor- and the substrate-binding site in glucose-6-phosphate (G6P) dehydrogenase. This combination of two inhibition mechanisms makes the clip highly effective and selective for this enzyme over other dehydrogenases.
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Stefania Filosa, Annalisa Fico, F Paglialunga et al. · Biochemical Journal · 2003 · 179 citations · Full text
Masayo Kotaka, S. Gover, Lucy Vandeputte-Rutten et al. · Acta Crystallographica Section D Biological Crystallography · 2005 · 177 citations · Full text