Dynamic Kinetic Resolution of α‐Substituted β‐Ketoesters Catalyzed by Baeyer–Villiger Monooxygenases: Access to Enantiopure α‐Hydroxy Esters

Abstract

BVMOs make a play: The dynamic kinetic resolution of racemic α-alkyl-β-ketoesters was performed through a selective Baeyer–Villiger oxidation employing different Baeyer–Villiger monooxygenases (BVMOs) in mild basic media. The product diesters were obtained with excellent yields and enantioselectivities, and used as precursors for optically active α-hydroxy esters.